RESUMEN
SOURCE CITATION: Husby A, Hansen JV, Fosbøl E, et al. SARS-CoV-2 vaccination and myocarditis or myopericarditis: population based cohort study. BMJ. 2021;375:e068665. 34916207.
Asunto(s)
Vacuna nCoV-2019 mRNA-1273 , COVID-19 , Miocarditis , Vacuna nCoV-2019 mRNA-1273/efectos adversos , COVID-19/epidemiología , COVID-19/prevención & control , Estudios de Cohortes , Humanos , Miocarditis/inducido químicamente , Miocarditis/epidemiología , SARS-CoV-2 , Vacunación/efectos adversosRESUMEN
An elderly patient with borderline tuberculoid Hansen's disease (leprosy) developed the diaminodiphenylsulphone syndrome after approximately 8 weeks of multi-drug therapy comprising dapsone and rifampicin. Postmortem histological examination, following autopsy, demonstrated features consistent with drug-induced hepatitis, tubulo-interstitial nephritis and myocarditis. Although these could have been engendered by dapsone toxicity, it was thought that a concommitant adverse reaction to rifampicin, which is known to be hepatotoxic, nephrotoxic and possibly capable of predisposing to the dapsone syndrome, could not be excluded.